Dichloromethane → HCID 131725969, compound

Participants

Reaction Steps

A solution was made containing tert-butyl (2S,4EZ)-4-(methoxyimino)-2-(3-methyl-1,2,4-oxadiazol-5-yl)-1-pyrrolidinecarboxylate (1.26 g, 4.25 mmol) in anhydrous DCM (120 ml). At 0° C., HCl gas, previously dried with a H2SO4 cc trap, was bubbled slowly through the reaction and deprotection was monitored by TLC using cyclohexane/ethyl acetate (1/1) and stained with a pancaldi solution. After approximately 45 minutes, TLC showed no remaining starting materiel and DCM was then evaporated under vacuo without heating to avoid pyrolidine salt decomposition. More DCM (20 ml) was then added and evaporated again under vacuo to remove remaining potential HCl (2–3 times). The desired product, (3EZ,5S)-5-(3-methyl-1,2,4-oxadiazol-5-yl)-3-pyrrolidinone O-methyloxime, hydrochloride salt, was isolated as a white solid and used without further purification and characterization

Provenance & Evidence