HRID1242557

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID30926

未命名化合物

2 次

HCID2782714

2'-(Trifluoromethyl)[1,1'-biphenyl]-4-carboxylic acid

C14H9F3O2

2 次

结构：CON=C1C[C@@H](C(=O)O)N(C(=O)OC(C)(C)C)C1

HCID58714586

(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

C11H18N2O5

2 次

PRODUCTS

生成物

结构：CON=C1C[C@@H](c2nc(C)no2)N(C(=O)c2ccc(-c3ccccc3C(F)(F)F)cc2)C1

HCID58714561

未命名化合物

收率 44%

PROCEDURE

实验过程

Following the general methods as outlined in Example 1 (Method B), starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidine-carboxylic acid (Intermediate 2), N′-hydroxyethanimidamide (Intermediate 7) and 2′-(trifluoromethyl) [1,1′-biphenyl]-4-carboxylic acid (Intermediate 10), the title compound was isolated, after flash-chromatography, as a mixture of E-/Z-isomers as an oil in 44% yield (88.2% purity by HPLC).