Formylglycine → {3-[(2S,4EZ)-1-([1,1'-biphenyl]-4-ylcarbonyl)-4-(methoxyimino)pyrrolidinyl]-1,2,4-oxadiazol-5-yl}methylformamide

Participants

Role	Name	HCID	Charge
Reactant	Formylglycine	HCID 75606	—
Reactant	(2S,4EZ)-1-([1,1'-biphenyl]-4-ylcarbonyl)-N'-hydroxy-4-(methoxyimino)-2-pyrrolidinecarboximidamide	HCID 90995821	—
Product	{3-[(2S,4EZ)-1-([1,1'-biphenyl]-4-ylcarbonyl)-4-(methoxyimino)pyrrolidinyl]-1,2,4-oxadiazol-5-yl}methylformamide	HCID 58714548	—

Reaction Steps

Following the general method as outlined in Example 15, starting from (2S,4EZ)-1-([1,1′-biphenyl]-4-ylcarbonyl)-N′-hydroxy-4-(methoxyimino)-2-pyrrolidinecarboximidamide (Intermediate 8) and (formylamino)acetic acid, the title compound was obtained in 72% purity by HPLC.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07115639B2
Source dataset	uspto-grants-2006_10
ORD ID	ord-890f05883b4c474eb00317b3b03e3553
Source note	uspto-grants-2006_10