Acetylglycine → N-({3-[(2S,4EZ)-1-([1,1'-biphenyl]-4-ylcarbonyl)-4-(methoxyimino)-pyrrolidinyl]-1,2,4-oxadiazol-5-yl}methyl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	Acetylglycine	HCID 10972	—
Reactant	(2S,4EZ)-1-([1,1'-biphenyl]-4-ylcarbonyl)-N'-hydroxy-4-(methoxyimino)-2-pyrrolidinecarboximidamide	HCID 90995821	—
Product	N-({3-[(2S,4EZ)-1-([1,1'-biphenyl]-4-ylcarbonyl)-4-(methoxyimino)-pyrrolidinyl]-1,2,4-oxadiazol-5-yl}methyl)acetamide	HCID 58714556	—

Reaction Steps

Following the general method as outlined in Example 15, starting from (2S,4EZ)-1-([1,1′-biphenyl]-4-ylcarbonyl)-N′-hydroxy-4-(methoxyimino)-2-pyrrolidinecarboximidamide (Intermediate 8) and (acetylamino)acetic acid, the title compound was obtained in 72% purity by HPLC. MS(ESI+): m/z=434.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07115639B2
Source dataset	uspto-grants-2006_10
ORD ID	ord-4ad9f3983fd046bd807c8f07b6adf302
Source note	uspto-grants-2006_10