3-(Dimethylamino)propanoic acid → HCID 58714583, Verbindung

HRID 1242582Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1242582
[C:1]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:6]=[CH:5][C:4]([C:7]([N:9]2[CH2:13][C:12](=[N:14][O:15][CH3:16])[CH2:11][C@H:10]2[C:17](=[N:19][OH:20])[NH2:18])=[O:8])=[CH:3][CH:2]=1.[CH3:27][N:28]([CH3:34])[CH2:29][CH2:30][C:31](O)=O>>[CH3:16][O:15][N:14]=[C:12]1[CH2:11][C@@H:10]([C:17]2[N:18]=[C:31]([CH2:30][CH2:29][N:28]([CH3:34])[CH3:27])[O:20][N:19]=2)[N:9]([C:7]([C:4]2[CH:3]=[CH:2][C:1]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[CH:6][CH:5]=2)=[O:8])[CH2:13]1

Komponenten

3

Edukt 2

HCID 2398283-(Dimethylamino)propanoic acidHCID 90995821(2S,4EZ)-1-([1,1'-biphenyl]-4-ylcarbonyl)-N'-hydroxy-4-(methoxyimino)-2-pyrrolidinecarboximidamide2×

Produkt 1

HCID 58714583HCID 58714583, VerbindungAusbeute 25 %

Versuchsvorschrift

Following the general method as outlined in Example 15, starting from (2S,4EZ)-1-([1,1′-biphenyl]-4-ylcarbonyl)-N′-hydroxy-4-(methoxyimino)-2-pyrrolidinecarboximidamide (Intermediate 8) and N,N-dimethyl-β-alanine, the title compound was obtained in 25% yield (91.5% purity by HPLC).

Quellen und Nachweise

ORD-Eintrag
ord-3a130d3ee6bb45fca3123b9d433b0169
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07115639B2

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