1-(1,1-Dimethylethyl) (3R)-1,3-piperidinedicarboxylate → HCID 58714560, compound

Participants

Reaction Steps

Following the general method as outlined in Example 15, starting from (2S,4EZ)-1-([1,1′-biphenyl]-4-ylcarbonyl)-N′-hydroxy-4-(methoxyimino)-2-pyrrolidinecarboximidamide (Intermediate 8) and (3R)-1-(tert-butoxycarbonyl)-3-piperidinecarboxylic acid, the title compound, tert-butyl (3R)-3-{3-[(2S,4EZ)-1-([1,1′-biphenyl]-4-ylcarbonyl)-4-(methoxyimino)pyrrolidinyl]-1,2,4-oxadiazol-5-yl}-1-piperidinecarboxylate, was obtained in 85% yield (96.5% purity by HPLC).

Provenance & Evidence