2-{4-[(Tert-butoxy)carbonyl]piperazin-1-yl}acetic acid → HCID 58714564, compound

Participants

Reaction Steps

Following the general method as outlined in Example 15, starting from (2S,4EZ)-1-([1,1′-biphenyl]-4-ylcarbonyl)-N′-hydroxy-4-(methoxyimino)-2-pyrrolidinecarboximidamide (Intermediate 8) and [4-(tert-butoxycarbonyl)-1-piperazinyl]acetic acid, the title compound, tert-butyl 4-({3-[(2S,4EZ)-1-([1,1′-biphenyl]-4-ylcarbonyl)-4-(methoxyimino)pyrrolidinyl]-1,2,4-oxadiazol-5-yl}methyl)-1-piperazinecarboxylate, was obtained in 75% yield (88% purity by HPLC).

Provenance & Evidence