4-Phenylbenzoyl chloride → HCID 58714537, compound

HRID 1242605Notes

Reaction equation

HRID 1242605 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[C:19]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:24]=[CH:23][C:22](C(Cl)=O)=[CH:21][CH:20]=1.O/[N:35]=[C:36](\[NH2:45])/[CH2:37][C:38](=[O:44])[N:39]1[CH2:43][CH2:42][CH2:41][CH2:40]1>>[CH3:15][O:14][N:13]=[C:11]1[CH2:10][C@@H:9]([C:16]2[O:18][N:45]=[C:36]([CH2:37][C:38](=[O:44])[N:39]3[CH2:43][CH2:42][CH2:41][CH2:40]3)[N:35]=2)[N:8]([C:6]([C:31]2[CH:30]=[CH:29][C:28]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)=[CH:33][CH:32]=2)=[O:7])[CH2:12]1

Participants

4

Reactant 3

HCID 841514-Phenylbenzoyl chlorideHCID 9583352(1Z)-N′-Hydroxy-3-oxo-3-(1-pyrrolidinyl)propanimidamideHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid2×

Product 1

HCID 58714537HCID 58714537, compound

Procedure

Following the general method as outlined in Example 59, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidine-carboxylic acid (Intermediate 2), [1,1′-biphenyl]-4-carbonyl chloride, and (1Z)-N′-hydroxy-3-oxo-3-(1-pyrrolidinyl)propanimidamide, the title compound was obtained in 89% purity by HPLC.

Sources & evidence

ORD record
ord-65e599d843e342b6b8140ff6016e4c4d
Source dataset
uspto-grants-2006_10
Patent number
US07115639B2

Reaction notes

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