4-Phenylbenzoyl chloride → HCID 58714512, compound

HRID 1242608Notes

Reaction equation

HRID 1242608 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[C:19]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:24]=[CH:23][C:22](C(Cl)=O)=[CH:21][CH:20]=1.[CH3:34][C:35]1[CH:39]=[C:38]([CH3:40])[N:37]([CH2:41][CH2:42][C:43](=[N:45]O)[NH2:44])[N:36]=1>>[CH3:15][O:14][N:13]=[C:11]1[CH2:10][C@@H:9]([C:16]2[O:18][N:44]=[C:43]([CH2:42][CH2:41][N:37]3[C:38]([CH3:40])=[CH:39][C:35]([CH3:34])=[N:36]3)[N:45]=2)[N:8]([C:6]([C:31]2[CH:30]=[CH:29][C:28]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)=[CH:33][CH:32]=2)=[O:7])[CH2:12]1

Participants

4

Reactant 3

HCID 841514-Phenylbenzoyl chlorideHCID 2746182265314-19-0HCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid2×

Product 1

HCID 58714512HCID 58714512, compound

Procedure

Following the general method as outlined in Example 59, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidine-carboxylic acid (Intermediate 2), [1,1′-biphenyl]-4-carbonyl chloride, and 3-(3,5-dimethyl-1H-pyrazol-1-yl)-N′-hydroxy-propanimidamide, the title compound was obtained in 79% purity by HPLC. MS(ESI+): m/z=485.3.

Sources & evidence

ORD record
ord-c0b462ba3a924ef287d6c7eeccd9a4b0
Source dataset
uspto-grants-2006_10
Patent number
US07115639B2

Reaction notes

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