反应详情

温度

180 °C

In a 100 ml round-bottomed flask, 1 eq. of the compound obtained in Step A, 10 eq. of polyphosphoric acid and 1 eq. of phosphoric anhydride are mixed together. The mixture is stirred for 3 hours at 180° C. and is then hydrolysed. Extraction with ether is carried out, and the organic phase is washed with water, dried over MgSO4 and evaporated under reduced pressure. The residue obtained is purified by chromatography on a silica gel column.

1. extractionExtraction with ether
2. washthe organic phase is washed with water
3. dry with materialdried over MgSO4
4. customevaporated under reduced pressure
5. customThe residue obtained
6. customis purified by chromatography on a silica gel column