HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(5-Chloro-2-phenyl-1-benzothiophen-3-yl)-1-ethanamine Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diboron | HCID 6328200 | — |
| Reactant | 2-(5-Chloro-2-phenyl-1-benzothiophen-3-yl)acetonitrile | HCID 21917246 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(5-Chloro-2-phenyl-1-benzothiophen-3-yl)-1-ethanamine Hydrochloride | HCID 12412184 | — |
Reaction Steps
3 eq. of diborane in tetrahydrofuran and 1 eq. of the nitrile obtained in Step D are introduced into a 100 ml round-bottomed flask, and the mixture is then heated at reflux for 2 hours. After cooling, 15 eq. of 6M HCl are added and the tetrahydrofuran is evaporated off under reduced pressure. The precipitate formed is filtered off and recrystallised.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07115752B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-ea530fb2e04645bdaa460681da639b7a |
| Source note | uspto-grants-2006_10 |