Acetonitrile → HCID 21062814, compound

Participants

Reaction Steps

The title compound was obtained by mixing the material from step 3 (500 mg, 2.71 mmol) in MeCN (11 mL) at rt under argon with DIEA (1.9 mL, 11 mmol). To this solution was then added Boc-piperazine (553 mgs, 3.0 mmol). The mixture was then warmed to 80–85° C. for 1.5 hrs (followed by analytical RP-HPLC). The solvent was evaporated under reduced pressure and water (30 mL) was added. The water was washed with DCM (3-×15 mL), and the DCM was dried with MgSO4, filtered, and removed in vacuuo to afford a 98% yield of the desired product. ES-MS: (M+H)+ 335.

Provenance & Evidence