4-chloro-6-ethylthieno[2,3-d]pyrimidine → HCID 21062827, compound

HRID 1242796Notes

Reaction equation

HRID 1242796 reaction equation
[C:1]([N:8]1[CH2:13][CH2:12][NH:11][CH:10]([CH3:14])[CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].Cl[C:16]1[C:17]2[CH:24]=[C:23]([CH2:25][CH3:26])[S:22][C:18]=2[N:19]=[CH:20][N:21]=1>>[CH2:25]([C:23]1[S:22][C:18]2[N:19]=[CH:20][N:21]=[C:16]([N:11]3[CH2:12][CH2:13][N:8]([C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2])[CH2:9][CH:10]3[CH3:14])[C:17]=2[CH:24]=1)[CH3:26]

Participants

3

Reactant 2

HCID 9161764-chloro-6-ethylthieno[2,3-d]pyrimidineHCID 2756810tert-Butyl 3-methylpiperazine-1-carboxylate

Product 1

HCID 21062827HCID 21062827, compoundYield 96%

Procedure

1-BOC-3-Methylpiperazine was coupled with 4-chloro-6-ethylthiopheno[2,3-d]pyrimidine according to Example 87. Yield=96%, ES-MS: (M+H)+ 363.

Sources & evidence

ORD record
ord-a92f74292bea428ab6c4bf8b8c5e2db7
Source dataset
uspto-grants-2006_10
Patent number
US07115741B2

Reaction notes

Loading…