4-chloro-6-ethylthieno[2,3-d]pyrimidine → HCID 58715089, compound

HRID 1242797Notes

Reaction equation

HRID 1242797 reaction equation
[C:1]([N:8]1[CH2:13][CH2:12][NH:11][C@H:10]([CH3:14])[CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].Cl[C:16]1[C:17]2[CH:24]=[C:23]([CH2:25][CH3:26])[S:22][C:18]=2[N:19]=[CH:20][N:21]=1>>[CH2:25]([C:23]1[S:22][C:18]2[N:19]=[CH:20][N:21]=[C:16]([N:11]3[CH2:12][CH2:13][N:8]([C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2])[CH2:9][C@H:10]3[CH3:14])[C:17]=2[CH:24]=1)[CH3:26]

Participants

3

Reactant 2

HCID 9161764-chloro-6-ethylthieno[2,3-d]pyrimidineHCID 2756811(R)-1-Boc-3-methylpiperazine

Product 1

HCID 58715089HCID 58715089, compoundYield 92%

Procedure

1-BOC-3-(R)-methylpiperazine was coupled with 4-chloro-6-ethylthiopheno[2,3-d]pyrimidine according to Example 87. Yield=92%, ES-MS: (M+H)+ 363.

Sources & evidence

ORD record
ord-8c1c3699dfdc4181a0d1cf7b3e85d093
Source dataset
uspto-grants-2006_10
Patent number
US07115741B2

Reaction notes

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