Ammonia → HCID 21062821, compound

Participants

Reaction Steps

4-(4-tert-Butoxycarbonyl-piperazin-1-yl)-6-ethyl-thieno[2,3-d]pyrimidine-2-carboxylic acid (102.3 mg) was dissolved in tetrahydrofuran (0.50 mL) and 1,1′-carbonyl-diimidazole (42.3 mg) was added. The reaction was stirred at room temperature for 30 minutes and ammonia (0.5 M in dioxane, 1.57 mL) was added. The reaction was stirred at room temperature for 8 days and concentrated to dryness. The residue was purified on silica gel (0% to 10% ethyl acetate/hexane over 30 minutes) giving the desired product. Yield=47%, ES-MS: (M+H)+ 392.

Provenance & Evidence