Acetyl chloride → HCID 21939446, compound

Participants

Reaction Steps

[4-(6-Ethyl-thieno[2,3-d]pyrimidin-4-yl)-piperazin-1-yl]-piperidin-3-yl-methanone (Example 294, 17.0 mg) was dissolved in methylene chloride (1.00 mL) and diisopropylethylamine (12.4 μL). Acetylchloride (3.7 μL) was added and the reaction was stirred at room temperature for 30 minutes. The reaction was applied to silica gel and the product was isolated by eluting from 0% to 4% methanol/methylene chloride over 45 minutes then 10% methanol/methylene chloride for 15 minutes. Yield=53%, ES-MS: (M+H)+ 402

Provenance & Evidence