HCID 21939956, compound → HCID 21939846, compound

HRID 1242917Notes

Reaction equation

HRID 1242917 reaction equation
[OH:1][CH:2]1[C:11]2[N:10]=[CH:9][C:8]([NH:12][C:13](=[O:15])[CH3:14])=[CH:7][C:6]=2[CH2:5][CH2:4][CH2:3]1>[O-2].[O-2].[Mn+4].C(Cl)(Cl)Cl>[O:1]=[C:2]1[C:11]2[N:10]=[CH:9][C:8]([NH:12][C:13](=[O:15])[CH3:14])=[CH:7][C:6]=2[CH2:5][CH2:4][CH2:3]1

Participants

4

Reactant 1

HCID 21939956HCID 21939956, compound

Product 1

HCID 21939846HCID 21939846, compoundYield 81.7%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

Manganese dioxide (4.47 g, 51.4 mmol) was added to chloroform (26 ml) solution of N-(8-hydroxy-5,6,7,8-tetrahydro-3-quinolinyl)acetamide (1.06 g, 5.14 mmol) obtained in 2), which was stirred at room temperature for 1 day. After completion of the reaction, the insoluble matters were filtered off, and the filtrate was concentrated under reduced pressure. Diisopropyl ether and hexane were added to the resulting residue, to give the titled compound (858 mg) as a colorless powder.

Workup

  1. customobtained in 2), which
  2. customAfter completion of the reaction
  3. filtrationthe insoluble matters were filtered off
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. additionDiisopropyl ether and hexane were added to the resulting residue

Sources & evidence

ORD record
ord-7b0846dcb44741b7aef6b8597781f507
Source dataset
uspto-grants-2006_10
Patent number
US07115750B1

Reaction notes

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