Hydrochloric Acid → [6-(Acetylamino)-1-oxo-3,4-dihydro-2(1H)-naphthalenylidene]acetic acid

Participants

Reaction Steps

0.5N Aqueous sodium hydroxide solution (190 ml) was added to an aqueous solution(60 ml) of 6-acetamido-1-tetralone (5.00 g, 24.6 mmol) and glyoxylic acid (9.05 g, 98.5 mmol) under ice-cooling, which was stirred at 60 for 16 hours. After cooling, concentrated hydrochloric acid was added to the reaction mixture. The precipitated crystals were collected, which was washed with water, to give the titled compound (3.73 g).

Provenance & Evidence