Hydrogen chloride-ethyl acetate → HCID 21939817, compound

HRID 1242939Notes

Reaction equation

HRID 1242939 reaction equation
C(OCC)(=O)C.Cl.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([NH:23][C:24]3[CH:44]=[CH:43][C:27]([C:28]([CH:30]4[CH2:35][CH2:34][CH2:33][N:32](C(OC(C)(C)C)=O)[CH2:31]4)=[O:29])=[CH:26][CH:25]=3)=[O:22])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1>>[ClH:8].[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[CH:16]=[CH:17][C:18]([C:21]([NH:23][C:24]3[CH:44]=[CH:43][C:27]([C:28]([CH:30]4[CH2:35][CH2:34][CH2:33][NH:32][CH2:31]4)=[O:29])=[CH:26][CH:25]=3)=[O:22])=[CH:19][CH:20]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 21939751HCID 21939751, compound

Product 1

HCID 21939817HCID 21939817, compoundYield 166.8%

Procedure

4N Hydrogen chloride-ethyl acetate (1 ml) was added to tert-butyl 3-[4-[[(4′-chloro[1,1′-biphenyl]-4-yl)carbonyl]amino]benzoyl]-1-piperidinecarboxylate (100 mg, 0.193 mmol) obtained in 1). One hour later, the solvent was distilled out under reduced pressure. Diisopropyl ether was added to the residue, to give the titled compound (73.3 mg) as a colorless powder.

Workup

  1. customobtained in 1)
  2. distillationOne hour later, the solvent was distilled out under reduced pressure
  3. additionDiisopropyl ether was added to the residue

Sources & evidence

ORD record
ord-754e8c99809141478d95f857121725ba
Source dataset
uspto-grants-2006_10
Patent number
US07115750B1

Reaction notes

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