Hydrogen chloride-ethyl acetate → HCID 21939974, compound

HRID 1242940Notes

Reaction equation

HRID 1242940 reaction equation
C(OCC)(=O)C.Cl.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([NH:23][C:24]3[CH:29]=[CH:28][C:27]([CH:30]([OH:44])[CH:31]4[CH2:36][CH2:35][CH2:34][N:33](C(OC(C)(C)C)=O)[CH2:32]4)=[CH:26][CH:25]=3)=[O:22])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1>>[ClH:8].[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[CH:16]=[CH:17][C:18]([C:21]([NH:23][C:24]3[CH:29]=[CH:28][C:27]([CH:30]([OH:44])[CH:31]4[CH2:36][CH2:35][CH2:34][NH:33][CH2:32]4)=[CH:26][CH:25]=3)=[O:22])=[CH:19][CH:20]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 21939926HCID 21939926, compound

Product 1

HCID 21939974HCID 21939974, compoundYield 181.7%

Procedure

4N Hydrogen chloride-ethyl acetate (1 ml) was added to tert-butyl 3-[[4-[[(4′-chloro[1,1′-biphenyl]-4-yl)carbonyl]amino]phenyl](hydroxy)methyl]-1-piperidinecarboxylate (100 mg, 0.192 mmol) obtained in Reference Example 78. One hour later, the solvent was distilled out under reduced pressure. Diisopropyl ether was added to the residue, to give the titled compound (79.8 mg) as a colorless powder.

Workup

  1. customobtained in Reference Example 78
  2. distillationOne hour later, the solvent was distilled out under reduced pressure
  3. additionDiisopropyl ether was added to the residue

Sources & evidence

ORD record
ord-1a84b07915d54ee0a21a517634a0b2f0
Source dataset
uspto-grants-2006_10
Patent number
US07115750B1

Reaction notes

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