1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 21939821, compound

Participants

Reaction Steps

N,N-Dimethylethylenediamine (0.64 ml), WSC (1.31 g), HOBt (1.05 g), and triethylamine (2.4 ml) were added to a tetrahydrofuran (50 ml) solution of 2-[4-[[(benzyloxy)carbonyl]amino]phenyl]acetic acid (1.5 g) obtained in Reference Example 90. After stirring for 20 hours, the reaction mixture was poured into water, and extraction was conducted using ethyl acetate. The organic layer was washed with water, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution, dried and then concentrated. The residue was recrystallized from ethyl acetate-hexane, to give the titled compound (1.72 g).

Provenance & Evidence