2-Methylindole → HCID 21940686, compound

Participants

Reaction Steps

Using general procedure A, 2-methylindole (165 mg, 1.26 mmol)) was coupled with 5-iodo-m-xylene (150 μL, 1.04 mmol). The crude product was purified by flash chromatography on silica gel (2×15 cm; hexane-ether 40:1; 15 mL fractions). Fractions 4–9 provided 232 mg (95% yield) of the product as a colorless oil. 1H NMR (300 MHz, CDCl3): δ 7.62–7.53 (m, 1H), 7.15–7.05 (m, 4H), 6.98 (s, 2H), 6.39 (s, 1H), 2.41 (s, 6H), 2.31 (d, J=1.0 Hz, 3H).

Provenance & Evidence