Triethylamine → N-(4-(Diethylamino)phenyl)-8-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxamide

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Reaction Steps

To 8-methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid (206 mg, 1.0 mmol) in DMF (1.5 mL) was added N,N-diethylphenylene diamine sulfate (262 mg, 1.0 mmol), Et3N (606 mg, 6.0 mmol), and TBTU (321 mg, 1.0 mmol) at 0° C. After stirred overnight, ice chips and 20 mL ethyl acetate were added. Organic layer was washed with water (3×10 mL), dried over MgSO4, and then concentrated. Purification by column chromatography provided the titled compound (170 m g, 48%). 1H NMR (300 MHz, DMSO-D6) δ 9.59 (s, 1H), 7.39 (d, J=9.3 Hz, 2H), 7.08 (t, J=7.8 Hz, 1H), 6.75 (d, J=7.8 Hz, 1H), 6.70 (d, J=7.8 Hz, 1H), 6.61 (d, J=9.0 Hz, 2H), 3.76 (s, 3H), 3.29 (q, J=6.9 Hz, 4H), 2.91–2.56 (m, 5H), 2.00 (m, 1H), 1.69 (m, 1H), and 1.06 (t, J=6.9 Hz, 6H). MS (ESI) positive ion 353 (M+H)+; negative ion 351 (M−H)−.

Provenance & Evidence