HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron tribromide → 8-Hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | Methyl 8-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate | HCID 13058286 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-Hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid | HCID 21940433 | 77% |
Reaction Steps
To 8-Methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid methyl ester (660 mg, 3.0 mmol) in dichloromethane (3.0 mL) was added BBr3 (1 M, 3.0 mL, 3.0 mmol) at −78° C. The mixture was stirred for 3 hour and then worked up to give 8-hydroxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid (470 mg, 2.3 mmol, 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07115767B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-09b52fc89f3f48d18289b28fd48140d8 |
| Source note | uspto-grants-2006_10 |