7-chloro-3-(4-methoxy-phenyl)-1-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidine-2-one → 3-(4-methoxy-phenyl)-1-methyl-7-phenylamino-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidine-2-one

Participants

Reaction Conditions

Reaction Steps

The mixture of 7-chloro-3-(4-methoxy-phenyl)-1-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidine-2-one (65 mg, 0.21 mmol) in aniline (1.0 mL) (Aldrich) was heated to 120° C. for 1 hour. After cooling, the reaction mixture was washed with hexanes (100 mL×4) and the crude product was re-crystallized from ethyl acetate-hexanes to give 3-(4-methoxy-phenyl)-1-methyl-7-phenylamino-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidine-2-one as an off-white solid. (Yield 76.0 mg, 98.7%).

Provenance & Evidence