HCID 21939346, compound → HCID 11281029, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7-chloro-1-cyclopropylmethyl-3-(4-methoxy-phenyl)-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidine-2-one (104 mg, 0.30 mmol) in aniline (2.0 mL) (Aldrich) was heated to 120° C. for 1.5 hours. After cooling, the reaction mixture was washed with hexanes (4×100 mL) and the crude product was purified by recrystallization from methanol-ethyl acetate to give 3-[-3-(4-methoxy-phenyl)-2-oxo-7-phenylamino-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-1-yl]-propionitrile as a white solid. (Yield 111 mg, 91.7%).

Provenance & Evidence