HCID 21939346, compound → HCID 11281060, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of 7-chloro-1-cyclopropylmethyl-3-(4-methoxy-phenyl)-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidine-2-one (129 mg, 0.37 mmol) in aniline (1.0 mL) (Aldrich) was heated to 120° C. for 5.5 hours. After cooling, the reaction mixture was washed with hexanes (4×100 mL) and the crude product was purified by preparative thin layer chromatography to give 1-cyclopropylmethyl-3-(4-methoxy-phenyl)-7-phenylamino-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidine-2-one as an off-white solid. (Yield 20.6 mg, 13.7%).

Provenance & Evidence