反应详情

In a flask equipped with a magnetic stirring bar and a rubber septum is dissolved the N-{(S)-1-hydroxy-3-phenyl-2-propyl}-5-benzyloxy-2-hydroxybenzamide in methanol. Nitrogen is bubbled through the solution and 10% Pd on charcoal is added. After flushing with nitrogen, the suspension is placed under hydrogen atmosphere and stirred for 2 hours. The suspension is flushed with nitrogen and filtered and rinsed over Celite. The filtrate is concentrated under vacuum. In this fashion is obtained N-{(S)-1-hydroxy-3-phenyl-2-propyl}-2,5-dihydroxybenzamide (85%).

1. customIn a flask equipped with a magnetic stirring bar
2. customNitrogen is bubbled through the solution and 10% Pd on charcoal
3. additionis added
4. customAfter flushing with nitrogen
5. customThe suspension is flushed with nitrogen
6. filtrationfiltered
7. washrinsed over Celite
8. concentrationThe filtrate is concentrated under vacuum