HuagongsheHuagongshe Chemistry Print Report · For research reference only
Estradiol → HCID 131725979, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Estradiol | HCID 5757 | — |
| Reactant | 4-Nitrobenzoic Acid | HCID 6108 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 131725979 | HCID 131725979 | — |
Reaction Steps
Inversion of the configuration of the 17-position of oestradiol was achieved using a Misunobu reaction. The complex formed by triphenylphosphine and DEAD was reacted with the 3-O-benzyl-17-□-estradiol BLE99051 and p-nitrobenzoic acid at 80° C. in toluene to give the 3-O-benzyl-17-□-p-nitrobenzoate-estradiol BLE99053.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07119081B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-048a247c6290469d8db3ed6afb91d74c |
| Source note | uspto-grants-2006_10 |