反应详情

温度

100 °C

2.12 g (5 mmol) of methyl 2-(4,6-dimethoxy-pyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate were dissolved in 50 ml of dioxane, 10 ml of 1 N KOH solution were added, and the mixture was stirred at 100° C. for 3 h. The solution was diluted with 300 ml of water and extracted with ethyl acetate to remove unreacted ester. The aqueous phase was then adjusted to pH 1–2 with dilute hydrochloric acid and extracted with ethyl acetate. After drying over magnesium sulfate and removal of the solvent by distillation, the residue was mixed with an ether/hexane mixture, and the precipitate which formed was filtered off with suction. After drying, 1.85 g (90%) of a white powder remained.

1. extractionextracted with ethyl acetate
2. customto remove unreacted ester
3. extractionextracted with ethyl acetate
4. dry with materialAfter drying over magnesium sulfate and removal of the solvent by distillation
5. additionthe residue was mixed with an ether/hexane mixture
6. customthe precipitate which formed
7. filtrationwas filtered off with suction
8. customAfter drying