Hydrogen Peroxide → 3-(3,4-Dichlorophenyl)-spiro (oxirane-2, 2'-indan)-1',3'-dione

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a suspension of 2-(3,4-dichloro-benzylidene)-indane-1,3-dione (1c) (1.6 g, 5.2 mmol) in MeOH (13 mL) was added hydrogen peroxide (30% solution, 3 mL). The mixture was cooled to 0° C. and sodium hydroxide (1N, 300 μL) was added dropwise. After addition was completed, stirring was continued at room temperature for 1 h. The mixture was then poured into water (5 mL) and the resulting solid was collected by filtration and washed with water and MeOH. After drying under high vacuum 3-(3,4-dichlorophenyl)-spiro (oxirane-2,2′-indan)-1′,3′-dione (1d) (1.6 g, 95% yield) was obtained.

Herkunft & Nachweise