HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → HCID 54095292, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 5,6-Dimethoxyindolin-2-one | HCID 222993 | — |
| Reactant | 3-(5-formyl-4-methyl-1H-pyrrol-3-yl)propanoic acid | HCID 15160752 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 54095292 | HCID 54095292 | 58.8% |
Reaction Steps
4-(2-Carboxyethyl)-2-formyl-3-methylpyrrole (90 mg), 97 mg 5,6-dimethoxy-2-oxindole, and 75 μL piperidine in 2 mL of ethanol were heated at 95° C. for 5 hours. The reaction mixture was cooled and concentrated. The residue was suspended in 6 N aqueous hydrochloric acid. The precipitate was filtered, washed with water to pH 6 and dried in a vacuum oven to give 104 mg (58%) of the title compound as a brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07119090B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-41e27870acdb43409dde9bfa46ef527b |
| Source note | uspto-grants-2006_10 |