HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → HCID 69032764, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 3-(5-formyl-2,4-dimethyl-1H-pyrrol-3-yl)propanoic Acid | HCID 1512520 | — |
| Reactant | 4-Methyl-1,3-dihydro-2H-indol-2-one | HCID 12579382 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 69032764 | HCID 69032764 | 37% |
Reaction Steps
3-(2-Carboxyethyl)-2,4-dimethyl-5-formylpyrrole (97.5 mg), 74 mg 4-methyl-2-oxindole, and 75 μL piperidine in 3 mL of ethanol were heated at 95° C. for 5 hours. The reaction mixture was cooled and concentrated. The residue was suspended in 6 N of aqueous hydrochloric acid. The precipitate was filtered, washed with water to pH 6 and dried in a vacuum oven overnight to give 60 mg (37%) of the title compound as a green solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07119090B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-2606008913774b8aa93fee2ef680a43c |
| Source note | uspto-grants-2006_10 |