Dimethyl 3'-ethoxy-3-nitrobiphenyl-4-malonate → 3'-Ethoxy-3-nitrobiphenyl-4-acetic acid

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Reaction Steps

Crude dimethyl 3′-ethoxy-3-nitrobiphenyl-4-malonate was heated at 100° C. in 60 mL 6 N hydrochloric acid for a total of 4 days and cooled. The precipitate was collected by filtration, washed with water and hexane and dried to give 4.7 g (77% yield based on 5-bromo-2-fluoronitrobenzene) of crude 3′-ethoxy-3-nitrobiphenyl-4-acetic acid as a light tan solid.

Provenance & Evidence