6-Phenyl-1,3-dihydro-indol-2-one → 5-[(1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid

Participants

Reaction Steps

4-(2-Carboxyethyl)-2-formyl-3-methylpyrrole (90.5 mg), 105 mg 6-phenyl-2-oxindole and 2 drops piperidine in 2 mL of ethanol were heated at 90° C. overnight. The reaction mixture was cooled and concentrated. The residue was suspended in 6 N aqueous hydrochloric acid. The precipitate was filtered, washed with water to pH 6 and dried in a vacuum oven overnight to give 146 mg (78%) of the title compound as a brown solid.

Provenance & Evidence