HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromopyridine → 4-Piperidinecarboxylic acid, 1-(2-pyridinyl)-, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromopyridine | HCID 7973 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-Piperidinecarboxylic acid, 1-(2-pyridinyl)-, ethyl ester | HCID 3815618 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
Potassium carbonate (52.5 g, 0.379 mol) was charged to a stirred solution of 2-Bromopyridine (60 g, 0.379 mol) and Ethylisonipecotate (59.7 g, 0.379 mol), at an ambient temperature before heating to 120° C. for 24 hours. The mixture was cooled to room temperature and propan-2-ol charged to the solution. The reaction mixture was then filtered and telescoped into preparation 1c.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07119088B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-fbe6a82fa9e34a43a8807792ebbf64e4 |
| Source note | uspto-grants-2006_10 |