2-Chloroethanol → HCID 21925549, compound

Participants

Reaction Steps

N,N-Diisopropylethylamine (80 μl, 0.62 mmol), followed by 2-Chloroethanol (52 μl, 0.78 mmol) were added to a solution of the amine from example 12 (200 mg, 0.52 mmol) in N,N-dimethylformamide (6 ml), and the reaction mixture was stirred at room temperature for 18 hours. The mixture was concentrated under reduced pressure and the residue was purified by column chromatography on silica gel using ethyl acetate:methanol:0.88 ammonia (90:10:1) as eluant, to give the title compound as an off-white solid (120 mg).

Provenance & Evidence