反应详情

A solution of 12.1 g of 4-[diethylaminomethyl]benzonitrile in 40 ml of toluene was added to a solution of methylmagnesium bromide (43 ml of a 3 M solution in diethyl ether) in 40 ml of toluene, and the mixture was heated to reflux. Completion of the reaction was followed by pouring into ice-water, extracting with methyl tert-butyl ether, adjusting the aqueous phase to pH 11-12 by adding NaOH, and renewed extracting with methyl tert-butyl ether. The organic phase was dried and the solvent was evaporated. 12.1 g of the title compound were obtained.

1. temperaturethe mixture was heated to reflux
2. extractionextracting with methyl tert-butyl ether
3. additionby adding NaOH
4. extractionrenewed extracting with methyl tert-butyl ether
5. customThe organic phase was dried
6. customthe solvent was evaporated