反应详情

温度

50 °C

A solution of 4-toluenesulfonic acid 4,4,4-trifluoro-3-hydroxybutyl ester (1.30 g, 4.36 mmol) in DMSO (7 mL) was treated with sodium azide (0.306 g, 4.71 mmol) at is ambient temperature and then heated at 50° C. for 23 h. The mixture was diluted with cold water and extracted with diethyl ether. The combined organic extracts were washed (brine), dried, and evaporated without heat to give the product as a yellow oil (0.737 g, 100%).

1. customat is ambient temperature
2. extractionextracted with diethyl ether
3. washThe combined organic extracts were washed (brine)
4. customdried
5. customevaporated
6. temperaturewithout heat