2-Amino-4-(trifluoromethyl)oxazole → HCID 9978023, compound

HRID 1243627Notes

Reaction equation

HRID 1243627 reaction equation
[F:1][C:2]([F:10])([F:9])[C:3]1[N:4]=[C:5]([NH2:8])[O:6][CH:7]=1.[F:11][C:12]1[CH:25]=[CH:24][C:23]2[O:22][C:21]3[C:16](=[CH:17][C:18]([F:26])=[CH:19][CH:20]=3)[CH:15]([C:27](O)=[O:28])[C:14]=2[CH:13]=1>>[F:1][C:2]([F:10])([F:9])[C:3]1[N:4]=[C:5]([NH:8][C:27]([CH:15]2[C:16]3[CH:17]=[C:18]([F:26])[CH:19]=[CH:20][C:21]=3[O:22][C:23]3[C:14]2=[CH:13][C:12]([F:11])=[CH:25][CH:24]=3)=[O:28])[O:6][CH:7]=1

Participants

3

Reactant 2

HCID 27631882-Amino-4-(trifluoromethyl)oxazoleHCID 21928639HCID 21928639, compound

Product 1

HCID 9978023HCID 9978023, compound

Procedure

The title compound, white solid, m.p. 259° C. and MS: m/e=397.1 (M+H+), is prepared in accordance with the general method of example 3c from 4-trifluoromethyl-oxazol-2-ylamine and 2,7-difluoro-9H-xanthene-9-carboxylic acid (CAS:[188028-26-4]).

Sources & evidence

ORD record
ord-b06f0d0e82bc4dae92cbcc09aaa7ac14
Source dataset
uspto-grants-2006_10
Patent number
US07119113B2

Reaction notes

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