2-Amino-4-(trifluoromethyl)oxazole → HCID 9952591, compound

HRID 1243628Notes

Reaction equation

HRID 1243628 reaction equation
[F:1][C:2]([F:10])([F:9])[C:3]1[N:4]=[C:5]([NH2:8])[O:6][CH:7]=1.[F:11][C:12]1[CH:13]=[CH:14][C:15]2[CH:16]([C:27](O)=[O:28])[C:17]3[C:22]([O:23][C:24]=2[CH:25]=1)=[CH:21][C:20]([F:26])=[CH:19][CH:18]=3>>[F:1][C:2]([F:10])([F:9])[C:3]1[N:4]=[C:5]([NH:8][C:27]([CH:16]2[C:17]3[CH:18]=[CH:19][C:20]([F:26])=[CH:21][C:22]=3[O:23][C:24]3[C:15]2=[CH:14][CH:13]=[C:12]([F:11])[CH:25]=3)=[O:28])[O:6][CH:7]=1

Participants

3

Reactant 2

HCID 27631882-Amino-4-(trifluoromethyl)oxazoleHCID 21928636HCID 21928636, compound

Product 1

HCID 9952591HCID 9952591, compound

Procedure

The title compound, white solid, m.p. 265° C. and MS: m/e=397.2 (M+H+), is prepared in accordance with the general method of example 3c from 4-trifluoromethyl-oxazol-2-ylamine and 3,6-difluoro-9H-xanthene-9-carboxylic acid (CAS:[188028-37-7]).

Sources & evidence

ORD record
ord-1a4d0e808f9e40a9841454ea9f4226c6
Source dataset
uspto-grants-2006_10
Patent number
US07119113B2

Reaction notes

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