5-(Trifluoromethyl)-1,3-oxazol-2-amine → HCID 9887009, compound

HRID 1243629Notes

Reaction equation

HRID 1243629 reaction equation
[F:1][C:2]([F:10])([F:9])[C:3]1[O:7][C:6]([NH2:8])=[N:5][CH:4]=1.[F:11][C:12]1[CH:13]=[CH:14][C:15]2[CH:16]([C:27](O)=[O:28])[C:17]3[C:22]([O:23][C:24]=2[CH:25]=1)=[CH:21][C:20]([F:26])=[CH:19][CH:18]=3>>[F:1][C:2]([F:10])([F:9])[C:3]1[O:7][C:6]([NH:8][C:27]([CH:16]2[C:17]3[CH:18]=[CH:19][C:20]([F:26])=[CH:21][C:22]=3[O:23][C:24]3[C:15]2=[CH:14][CH:13]=[C:12]([F:11])[CH:25]=3)=[O:28])=[N:5][CH:4]=1

Participants

3

Reactant 2

HCID 219286275-(Trifluoromethyl)-1,3-oxazol-2-amineHCID 21928636HCID 21928636, compound

Product 1

HCID 9887009HCID 9887009, compound

Procedure

The title compound, white solid, m.p. 249° C. and MS: m/e=379.2 (M+H+), is prepared in accordance with the general method of example 3c from 5-trifluoromethyl-oxazol-2-ylamine and 3,6-difluoro-9H-xanthene-9-carboxylic acid.

Sources & evidence

ORD record
ord-5e932c5959d34fffaa144ddd9a1bc510
Source dataset
uspto-grants-2006_10
Patent number
US07119113B2

Reaction notes

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