2-Amino-4-(trifluoromethyl)oxazole → HCID 10475756, compound

HRID 1243630Notes

Reaction equation

HRID 1243630 reaction equation
[F:1][C:2]([F:10])([F:9])[C:3]1[N:4]=[C:5]([NH2:8])[O:6][CH:7]=1.[Cl:11][C:12]1[CH:25]=[CH:24][C:23]2[O:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]([C:26](O)=[O:27])[C:14]=2[CH:13]=1>>[F:1][C:2]([F:10])([F:9])[C:3]1[N:4]=[C:5]([NH:8][C:26]([CH:15]2[C:14]3[CH:13]=[C:12]([Cl:11])[CH:25]=[CH:24][C:23]=3[O:22][C:21]3[C:16]2=[CH:17][CH:18]=[CH:19][CH:20]=3)=[O:27])[O:6][CH:7]=1

Participants

3

Reactant 2

HCID 27631882-Amino-4-(trifluoromethyl)oxazoleHCID 21928629HCID 21928629, compound

Product 1

HCID 10475756HCID 10475756, compound

Procedure

The title compound, white solid, m.p. 235° C. and MS: m/e=395.2, 397.2 (M+H+) is prepared in accordance with the general method of example 3c from 4-trifluoromethyl-oxazol-2-ylamine and (RS)-2-chloro-9H-xanthene-9-carboxylic acid (CAS:[188027-67-0]).

Sources & evidence

ORD record
ord-0337e15b7025491abcdb352649167140
Source dataset
uspto-grants-2006_10
Patent number
US07119113B2

Reaction notes

Loading…