Water → HCID 21930273, compound

Participants

Reaction Conditions

Reaction Steps

In an open vial, 3-furan-2-yl-1-(4-phenoxy-phenyl)-propenone (0.4 g) was dissolved in dimethylsulfoxide (10 mL). Methylhydrazine (1.0 g) was added and the reaction mixture was heated to 85° C. for 3 days. The reaction mixture was cooled to room temperature and ethyl acetate (100 mL) and water (50 mL) were added. The organic layer was washed twice with water (25 mL), then separated and dried over sodium sulfate. The solvent was removed after filtering away the drying agent. Purification by column chromatography (silica, eluted with ethyl acetate-hexanes, 1:9) gave the desired pyrazole in moderate yield (0.1 g).

Provenance & Evidence