Triethyl phosphite → HCID 21065007, compound

Participants

Reaction Conditions

Reaction Steps

To a 30 mL vial, 1-(2-iodo-4-bromophenyl)-3-(3-trifluoromethylphenyl)urea (2.00 g, 4.12 mmol) was added along with triethylphosphite (1.03 g, 6.0 mmol) and PdCl2 (49 mg, 0.278 mmol). The vial was flushed with N2 sealed and then heated at 130° C. while stirring overnight. The resulting solution was cooled to room temperature, dissolved in a 1:1 mixture of EtOAc/hexane and then purified on a silica column using mixtures of EtOAc/hexanes to give 1.25 g of 1-(2-diethylphosphono-4-bromophenyl)-3-(3-trifluoromethylphenyl)urea as a white solid.

Provenance & Evidence