Thionyl Chloride → HCID 21930283, compound

HRID 1243655Notes

Reaction equation

HRID 1243655 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:11][S:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=2)(=[O:14])=[O:13])=[C:6]([CH:10]=1)[C:7](O)=[O:8].S(Cl)([Cl:28])=O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:11][S:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=2)(=[O:14])=[O:13])=[C:6]([CH:10]=1)[C:7]([Cl:28])=[O:8]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 21930289HCID 21930289, compound

Product 1

HCID 21930283HCID 21930283, compound

Procedure

5-Bromo-2-(4-trifluoromethoxy-benzenesulfonylamino)-benzoic acid (3.27 g, 7.4 mmol) was suspended in thionyl chloride (30 mL). The mixture was heated to reflux for 4 hours. The solvent was removed to dryness. The residue was dissolved in anhydrous ethyl acetate and solvent removed (2×20 mL). The solid was dried at 40° C. in vacuum oven overnight.

Workup

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 4 hours
  3. customThe solvent was removed to dryness
  4. dissolutionThe residue was dissolved in anhydrous ethyl acetate
  5. customsolvent removed (2×20 mL)
  6. customThe solid was dried at 40° C. in vacuum oven overnight

Sources & evidence

ORD record
ord-3ce9b3734a7e4075b18f785266bdbe12
Source dataset
uspto-grants-2006_10
Patent number
US07119120B2

Reaction notes

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