HCID 21064711, compound → HCID 21928101, compound

Participants

Reaction Steps

6-(2-tert-Butoxycarbonylamino-1-hydroxy-ethyl)-nicotinic acid methyl ester (137.3 mg, 0.450 mmol) was dissolved into 3 mL of MeOH. To this was added LiOH monohydrate (56.5, 1.350 mmol). The reaction stirred at room temperature overnight. The reaction mixture was concentrated on a rotary evaporator, dissolved into 2 mL of water, and brought to pH 4 with AcOH. The mixture was extracted into 3×10 mL of EtOAc and the organic fractions combined. The organic phase was washed with 2×20 mL H2O and 1×20 mL of brine, dried MgSO4, filtered and concentrated to give 130 mg of 6-(2-tert-butoxycarbonylamino-1-hydroxy-ethyl)-nicotinic acid.

Provenance & Evidence