Potassium Carbonate → HCID 86600248, compound

Participants

Reaction Steps

Dissolved acetic acid (R)-2-azido-1-(6-methyl-pyridin-2-yl)-ethyl ester (2.20 g, 9.90 mmol) into 50 mL of MeOH. To this was added K2CO3 (1.50 g) and the heterogenous mixture stirred for 2 h. LC-MS analysis indicated completion of the reaction. The mixture was concentrated and 100 mL of H2O was added. The mixture was extracted with 2×100 mL of CH2Cl2, dried with MgSO4, filtered and concentrated to give 1.78 g of (R)-2-azido-1-(6-methyl-pyridin-2-yl)-ethanol. ee % >99.

Provenance & Evidence