HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-6-hydroxypicolinic acid → 5-fluoro-6-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoro-3-pyridyl)-5-methyl-2-imidazolin-2-yl]-2(1H)-pyridinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-6-hydroxypicolinic acid | HCID 21928318 | — |
| Reactant | (2S)-1-(4-fluorophenyl)-1-(6-fluoro-3-pyridyl)-1,2-propanediamine | HCID 58649654 | — |
| Product | 5-fluoro-6-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoro-3-pyridyl)-5-methyl-2-imidazolin-2-yl]-2(1H)-pyridinone | HCID 178461608 | — |
Reaction Steps
According to the method of Example 1, optically active (2S)-1-(4-fluorophenyl)-1-(6-fluoro-3-pyridyl)-1,2-propanediamine described in Reference Example 5–1 of WO 01/62738 was reacted with 3-fluoro-6-oxo-1,6-dihydro-2-pyridinecarboxylic acid to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07119107B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-fac0f7224f274e23a3db364e2e23bf70 |
| Source note | uspto-grants-2006_10 |