Azetidine → azetidin-1-yl(6,6-diphenyl-6,7-dihydro-1H-indazol-3-yl)methanone

Participants

Reaction Conditions

Reaction Steps

0.256 g of 1-hydroxybenzotriazole hydrate and 0.364 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride are added to 0.5 g of 6,6-diphenyl-6,7-dihydro-1H-indazole-3-carboxylic acid in suspension in 100 cm3 of dichloromethane. After stirring for 30 minutes at a temperature in the region of 20° C., a solution of 0.114 g of azetidine and 0.303 g of triethylamine in 10 cm3 of dichloromethane is added to the reaction mixture. After stirring at a temperature in the region of 20° C. for about 20 hours, the reaction mixture is diluted with 300 cm3 of dichloromethane and then washed with 3 times 100 cm3 of water. The resulting organic phase is dried over magnesium sulphate, filtered and then concentrated to dryness under reduced pressure (13 kPa). The residue is purified by flash chromatography on a column of silica [eluent: dichloromethane/methanol (95/5 by volume)] to give 0.37 g of azetidin-1-yl(6,6-diphenyl-6,7-dihydro-1H-indazol-3-yl)methanone, in the form of a white powder, the characteristics of which are as follows:

Provenance & Evidence